The materials are produced under a third-party certified ISO 13485:2016 quality management system and backed by comprehensive change control of raw materials, formulation, and manufacturing standards to enable consistent batch-to-batch quality.”

¹PCF values are calculated with Avient’s TÜV certified PCF-Calculator according to ISO 14067.  

Mevopur™ Colorants represent a broad range of color concentrates and formulations, developed specifically for use in today’s complex healthcare applications, which meet or exceed requirements for regulations such as USP Class VI, ISO 10993, USP 661 and ICH Q3D.

These values were determined using Avient’s PCF Calculator, which is third-party certified by TÜV Rheinland and aligns with ISO-14067:2018 standards.

e-Certificate of registration Swedish Companies Registration Office LIMITED COMPANY D1a- 6064988 Registration number Date of registration of the company Document created on Date of registration of current name Page 556393-1020 1990-04-10 2020-11-30 14:53 2020-11-30 1 (2) Registration number: 556393-1020 Business name: Avient Colorants Sweden AB Address: Box 9053 200 39 MALMÖ Registered office: Malmö Note: The company is registered as a private limited company. THE COMPANY WAS FORMED 1990-03-29 SHARE CAPITAL Share capital...: SEK 3,200,000 Min.............: SEK 3,000,000 Max.............: SEK 12,000,000 Number of shares: 32,000 Min.............: 30,000 Max.............: 120,000 BOARD MEMBER, MANAGING DIRECTOR 660613-3954 Nilsson, Bo Patrik Joakim, Hovslagaregatan 13, 271 57 YSTAD BOARD MEMBER, CHAIR OF THE BOARD 640503 Merklein, Norbert, Fichtenstrasse 20, 61476 KRONBERG IM TAUNUS, TYSKLAND BOARD MEMBERS 750618-4089 Norén, Jenny Eva Kristina, Fårabäcksvägen 68, 212 91 MALMÖ 610322 Smeds, Jan-Håkan, Chämiweg 23, NEFTENBACH, TYSKLAND AUDITORS 556029-6740 Öhrlings PricewaterhouseCoopers AB, Box 4009, 203 11 MALMÖ Represented by: 710921-4689 PRINCIPALLY RESPONSIBLE AUDITOR 710921-4689 Olsson, Karin Maria, c/o PwC, 405 32 GÖTEBORG SIGNATORY POWER e-Certificate of registration Swedish Companies Registration Office LIMITED COMPANY D1a- 6064988 Registration number Date of registration of the company Document created on Date of registration of current name Page 556393-1020 1990-04-10 2020-11-30 14:53 2020-11-30 2 (2) The board of directors is entitled to sign.

H Y P O D E R M I C N E E D L E M A N U FAC T U R E R N E E D L E H U B , C O V E R A N D S H I E L D • Compliance to ISO 6009 color coding for single use hypodermic needle • Biocompatibility of all component materials • Good mechanical and visual properties after sterilization (e.g. ETO / Gamma radiation) • Facilitated 510(k) submission with formulations registered under Device Master File MAF 1833 • Pre-tested raw materials to biocompatibility ISO10993, US and Eu Pharmacopeia, ICH-Q3D extractable metals • Enhanced stability with gamma stabilizing package • Minimized risk of change with change control beyond CAS number level • Ensured uninterrupted supply from multiple ISO 13485-2016 certified sites • MEVOPURTM ISO 6009 Standard / Customized Solutions KEY REQUIREMENTS WHY AVIENT?

Roman, Secretary of State of the Government of Puerto Rico, CERTIFY: That on July 13, 2020, at 08:50 AM, "POLYONE PUERTO RICO, LLC", registry number 365432, performed the following transaction: Name Change Previous Actual POLYONE PUERTO RICO, LLC AVIENT PUERTO RICO, LLC CERTIFICATE OF AMENDMENT Government of Puerto Rico IN WITNESS WHEREOF, the undersigned by virtue of the authority vested by law, hereby issues this certificate and affixes the Great Seal of the Government of Puerto Rico, in the City of San Juan, Puerto Rico, today, July 13, 2020.

In addition, Avient has externally certified EHS&S management systems, including ISO 9001 worldwide. Additionally, 52% of our facilities are certified to ISO 14001, 56% to Responsible Care 14001 and ISO 45001, and 10% of our high energy sites are certified to ISO 50001. Additionally, 52% of our facilities are certified to ISO 14001, 56% to Responsible Care 14001 and ISO 45001, and 10% of our high energy sites are certified to ISO 50001.