Cesa Fiber Additives for Heat Preservation Technical Bulletin_CN2.2-2

Mevopur Healthcare Functional Additives Medical Devices Application Bulletin_CN12.15-2

CORE(TM) MB3140A LT. CORE(TM) SK468 (SB-BO-P) CORE(TM) SK469 (SB-RD-P)

Geon(TM) FB577 Black Geon(TM) FB573 Brown Geon(TM) FB599 BLACK FOAM

CORE(TM) MB3199B TRANS PINK CORE(TM) MB3199C TRANS PINK CORE(TM) DB5580 YELLOW PMS 396

Geon(TM) MB2990 White 85 NP Geon(TM) DB5309 CLEAR Geon(TM) DB5342 Yellow 90

DNU Geon(TM) A58-76L FILTER Geon(TM) V1837-81 Scrim Coat Geon(TM) A61-21B Top Coat

SynPrime(TM) 20SB SynPrime(TM) 40PH SynPrime(TM) 25PH

Geon(TM) DB5217 RED 1208 Geon(TM) DB5218 NEUTRAL SOFT Geon(TM) DB1587A FLOWSERVE RED

Mevopur™ Healthcare Functional Additives Laser Welding Additives for Medical Devices Laser welding has become a technology of choice to join plastic parts of complex medical devices. Avient uses a “systems approach” to develop the laser welding solution most adapted to your project, taking into consideration the following aspects: • Transmitting and absorbing parts • Polymer type and grade • Dispersion of the additive in the final part • Sufficient and consistent loading of the additive • Part design: attention to flow separation at the welding interface • Color and opacitiy • Quality control – e.g. establish suitable control parameters (UV Visible Spectra) • Laser wavelength and processing parameter Mevopur™ Healthcare Functional Additives formulated for laser welding are designed for use in healthcare applications. KEY CHARACTERISTICS • Manufactured at four ISO 13485 certified sites, providing global consistency and increased security of supply • Documented change control beyond CAS number, reducing risk of change • Available as additive concentrates, ready-to-use additive formulations or ready-to-use additive/ colorant formulations for different polymers REGULATORY SUPPORT • Raw materials tested to: - ISO 10993-1 and USP biological evaluation - European Pharmacopeia 3.1.3/3.1.5 (polyolefin) - USP (polyethylene) - ICH Q3D elemental impurities • Registered Drug Master File (Type III) and/or Device Master File • Food contact established with FDA/EU* APPLICATION BULLETIN * FDA/EU compliance information available upon request; exceptions may occur Healthcare use limitations apply—see below.